INTERACCIÓN ENTRE INHIBIDORES Y SEROTONINA TAMOXIFENO RECAPTACIÓN: UNA REVISIÓN DE LA LITERATURA
Maiara Priscila dos Passos, Flavia Valladão Thiesen, Ana Paula Duarte de Souza, Luciana Mello de Oliveira

Objective: To performe a literature review on drug interactions in patients who are under concomitant use of tamoxifen and serotonin reuptake inhibitors.

Methods: A keyword research was conducted using the terms “drug interactions,” “tamoxifen,” and “depression” in the PUBMED database; “antidepressive agents,” “antidepressants,” and “tamoxifen” in LILACS; “tamoxifen,” “drug interactions,” and “depression” in EMBASE. Studies published from 2005 to 2015, in Portuguese, English, and Spanish were considered.

Results: The research returned 80 articles. Duplicates and those that did not meet the criteria were excluded. As result, 14 articles were considered in the study.

Conclusion: There is a important interaction between serotonin reuptake inhibitors and tamoxifen. The concomitant use of both drugs should be avoided in order to prevent serious side effects.

Descriptores: El tamoxifeno, Depresión, agentes antidepresivos.