NOTIFICATION OF ADVERSE REACTIONS IN A SENTINEL HOSPITAL OF FORTALEZA – CEARÁ
Geysa Aguiar Romeu; Melissa Rocha Fernandes Távora; Ana Kéllen Mota da Costa; Mariana Oliveira Brizeno de Souza; Ana Paula Soares Gondim;

This article aims to describe the reports of suspected adverse drug reactions in a sentinel hospital in Fortaleza, Ceara state, and retrospective descriptive study that used as a secondary source, the notification form of suspected adverse reactions to drugs the pharmacovigilance system in 2007. There were 116 reports involving 269 drugs and 204 reactions. Only 0.9% of notifications were made spontaneously. The age group ranged from 2 to 87 years with an average of 33 (± 20.1) years. The adverse reactions mainly men (81.9%), between 15 and 29 years (42.4%). The main drugs involved were metamizol (32.8%) and cephalothin (27.6%). It was also found that the integumentary system (59.3%) and gastrointestinal system (13.2%) understood the systems most affected by adverse reactions. The most frequent reactions included urticaria (23.3%), pruritus (16.8%), skin rash, abdominal pain and allergic processes (5.9% each). Also has reported serious adverse reactions such as Steven Johnson syndrome (3.9%). It was noted the need for more investment in this area, especially in relation to awareness of the importance of spontaneous reporting to obtain data necessary for purposes of health regulations.

Descriptors: Pharmacovigilance. Notification. Adverse drug reaction. Sentinel Hospital.