Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
Brazilian Journal of Hospital Pharmacy and Health Services
Revista Brasileña de Farmácia Hospitalaria y Servicios de Salud
Quinta, 25 de Abril de 2019 ISSN impresso: 2179-5924
ISSN online: 2316-7750
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Revista Associada
 
Volumes: 123456789 Números: 1234

PERFIL DE USO DE ANTIMICROBIANOS EN LA UNIDAD DE CUIDADOS INTENSIVOS DE UN HOSPITAL PÚBLICO
Flávia Carvalho de Souza, Marcia Maria Ferreira Baroni, Fabiana Mesquita Roese

Objective: to evaluate and quantify the use of antimicrobials used in the intensive care unit (ICU) of a Public Hospital in relation to the Anatomical Therapeutic Chemical / Daily Definite Dose (ATC/DDD) methodology.

Methodology: a cross-sectional, descriptive, quantitative and retrospective study was carried out between January 1 and March 31, 2016. The calculation of the DDD per 100 bed-days defined by Gomes and Reis was used.

Results: in the study of DDD / 100-day observation greater than the findings in the literature, with values for Meropenem (77.71), Polimixin E (57.89), Linezolide (20.01), Teicoplanin (19.85), Cefepime (19,06), Polymyxin B (17,54), Micafungin (16,19), Tigecycline (15,55) and Amicacin (14,12). The differences in DDD / 100-day-days found in the literature show: a local epidemiology; Microbiological profile of each hospital; The period studied; The implanted clinical protocols; More serious infections as well as bacterial resistance in the hospital environment.

Conclusions: the high use of meropenem may have been influenced by the severity of the patient's condition as well as the prescription of empirical therapy. As for the others more consumed were used in associations in the therapy to reach the clinical and therapeutic improvement of the patient. Therefore, it is important to encourage new research by correlating DDD with the microbiological profile of patients in the ICU, and pharmacovigilance and pharmacoeconomics studies, in order to work to reduce morbidity and mortality rates and to reduce costs for institution.

Descriptores: Palabras-clave: Unidad de Cuidados Intensivos; antimicrobianos; Dosis diaria definida.

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