Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
Brazilian Journal of Hospital Pharmacy and Health Services
Revista Brasileña de Farmácia Hospitalaria y Servicios de Salud
Quinta, 25 de Abril de 2019 ISSN impresso: 2179-5924
ISSN online: 2316-7750
::
 
Revista Associada
 
Volumes: 123456789 Números: 1234

DISEÑO, MANEJO Y EVALUACIÓN DE LA CALIDAD DE LOS POLVOS MEDICADOS QUE CONTIENEN CAPTOPRIL DIVIDIDAS PARA USO PEDIÁTRICO
Bruna David de Souza, Raphael Fernando Boiatti, Denilton Silva Costa, Juliana Aparecida Severi, Janaina Cecília Oliveira Villanova

Pediatric patients require different dosage forms from adults due to differences in swallowing capacities, taste preferences, and dosage requirements. Most medicines are produced for adults as capsules and tablets. These formulations are not suitable for children, which often leads to off-label and unlicensed use of adult medicines. These preparations are often prescribed by pediatricians due to the absence of others replace them. In this context, consider the drug preparation in another pharmaceutical dosage form is the responsibility of the pharmacist.

Objectives: the aim of the present study was to design solid dosage forms containing captopril for prior solubilization in small volumes of water before administration. Solid dosage forms are more stable than liquids and the reconstituted solutions can be sweetened and flavored

Methods: quality control tests were performed in the captopril and in the each batch of dosage forms in accordance with official and validated methods. The formulations were compounded by geometric dilution.

Results: captopril complied with the pharmacopoeial requirements (aspect, identification, pH, solubility, and melting point). The use of compressible sucrose and sorbitol as singles diluents, as well as the combination thereof with lactose M200, originated solutions clear, without particles in suspension, and sweetened. The divided powders were approved in the quality assays (average weight, dose uniformity and drug content).

Conclusions: according with the results, it was possible to prepare medicated powders containing 6.25 mg of captopril, with intention to minimize the lack of existing antihypertensive pediatric formulations in the national market.

Descriptores: Pacientes pediátricos, captopril, polvos medicados

Resumo/Abstract/Resumen => Português | English | Español Artigo/Article/Articulo => Português |  English |  Español


Parceiros
Revista RBFHSS - Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
® 2010-2019 - Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde - Todos os direitos reservados
Rua Vergueiro, 1855 - 11. Andar - Vila Mariana CEP 04101-000 - São Paulo/SP - Fone/Fax: 011 5083-4297
Desenvolvido e Mantido por: LAB Graphic